J. ПОФ и сигнальные пути КМГП  

J. ПОФ и сигнальные пути КМГП

Ahn J, Serrano de la Peña L, Shore EM, Kaplan FS. aresis of a bone morphogenetic protein – antagonist response in a genetic disorder of heterotopic skeletogenesis. J Bone Joint Surg Am 85: 667-674, 2003

Billings PC, Fiori JL, Bentwood JL, O’Connell MP, Jiao X, Nussbaum B, Caron RJ, Shore EM, Kaplan FS. Dysregulated КМГП signaling and enhanced osteogenic differentiation of connective tissue progenitor cells from patients with fibrodysplasia ossificans progressiva. J Bone Miner Res 23: 305-313, 2008

Fiori JL, Billings PC, Serrano de la Peña L, Kaplan FS, Shore EM. Dysregulation of the КМГП-p38 MAPK signaling pathway in cells from patients with fibrodysplasia ossificans progressiva. J Bone Miner Res 21: 902-909, 2006

Fukada T, Kohda M, Kanomata K, Nojima J, Kamizono J, Oda H, Nakayama K, Ohtake A, Miyazono K, Jimi E, Owan I, Okazaki Y, Katagiri T. A constitutively activated КМГП receptor, ALK2, induces heterotopic bone formation in patients with fibrodysplasia ossificans progressiva. J Bone Miner Res 22 (suppl. 1); S10, 2007

Gannon FH, Kaplan FS, Olmsted E, Finkel G, Zasloff MA, Shore EM. Bone morphogenetic protein 2/4 in early fibromatous lesions of fibrodysplasia ossificans progressiva. Hum Pathol 28: 339-343, 1997

Glaser DL, Economides AN, Wang L, Liu X, Kimble RD, Fandl JP, Wilson JM, Stahl, N, Kaplan FS, Shore EM. In vivo somatic cell gene transfer of an engineered noggin mutein prevents BMP4-induced heterotopic ossification. J Bone Joint Surg Am 12: 2332-2342, 2003

Hegyi L, Gannon FH, Glaser DL, Shore EM, Kaplan FS, Shanahan CM. Stromal cells of fibrodysplasia ossificans progressiva lesions express smooth muscle lineage markers and the osteogenic transcription factor Runx2/Cbfa-1: Clues to a vascular origin of heterotopic ossification? J Pathol 201: 141-148, 2003

Kaplan FS, Groppe J, Pignolo RJ, Shore EM. Morphogen receptor genes and metamorphogenes: skeleton keys to metamorphosis. Ann NY Acad Sci 1116: 113-133, 2007

Kaplan FS, Tabas JA, Zasloff MA. Fibrodysplasia ossificans progressiva: A clue from the fly? Calcif Tiss Int 47: 117-125, 1990



O’Connell MP, Billings PC, Fiori JL, Deirmengian G, Roach HI, Shore EM, Kaplan FS. HSPG modulation of КМГП signaling in fibrodysplasia ossificans progressiva cells. J Cell Biochem 102: 1493-1503, 2007

Roush W. Protein builds second skeleton. Science 273: 1170, 1996

Serrano de la Peña L, Billings PC, Fiori JL, Ahn J, Shore EM, Kaplan FS. Fibrodysplasia ossificans progressiva (ПОФ), a disorder of ectopic osteogenesis, misregulates cell surface expression and trafficking of BMPRIA. J Bone Miner Res 20: 1168-1176, 2005

Shafritz AB, Shore EM, Gannon FH, Zasloff MA, Taub R, Muenke M, Kaplan FS. Overexpression of an osteogenic morphogen in fibrodysplasia ossificans progressiva (ПОФ). N Engl J Med 335: 555-561, 1996


Shen Q, Xu M, Little SC, Kaplan FS, Mullins MC, Shore EM. Activation of КМГП signaling by the ПОФ ACVR1 R206H mutation. J Bone Miner Res 22 (suppl. 1); S43, 2007

Shore EM, Xu M, Feldman GJ, Fenstermacher DA, Cho T-J, Choi IH, Connor JM, Delai P, Glaser DL, Le Merrer M, Morhart R, Rogers JG, Smith R, Triffitt JT, Urtizberea JA, Zasloff M, Brown MA, Kaplan FS. A recurrent mutation in the КМГП type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. Nature Genetics 38: 525-527, 2006


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